Monitoring molecular recognition of the ribosomal decoding site.
نویسندگان
چکیده
Fidelity during protein synthesis is maintained by the ribosomal decoding site which monitors base pairing between the mRNA codon and the tRNA anticodon. Binding of cognate tRNA induces conformational changes in ribosomal RNA (rRNA) at the decoding site that translate into a signal for the progression of translation. An internal loop containing adenine residues A1492 and A1493 in 16S rRNA of the 30S (small) ribosomal subunit constitutes a major component of the bacterial decoding site (Figure 1a). Contacts of the
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 43 24 شماره
صفحات -
تاریخ انتشار 2004